Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats
Identifieur interne : 003196 ( Main/Exploration ); précédent : 003195; suivant : 003197Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats
Auteurs : Vemuganti L. Raghavendra Rao [États-Unis] ; Aclan Dogan [États-Unis] ; Kathryn G. Todd [Canada] ; Kellie K. Bowen [États-Unis] ; Robert J. Dempsey [États-Unis]Source :
- Brain Research [ 0006-8993 ] ; 2001.
English descriptors
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Abstract
This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.
Url:
DOI: 10.1016/S0006-8993(01)02617-8
Affiliations:
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